Goodmans gpr40 software

Nat Immunol. Brain Behav Immun. Bliverdin reductase-A improves neurological function in a germinal matrix hemorrhage rat model. Neurobiol Learn Mem.

Anti-inflammation conferred by stimulation of CDR1 via Dok1 pathway in rat microglia after germinal matrix hemorrhage.

Dabigatran ameliorates post-haemorrhagic hydrocephalus development after germinal matrix haemorrhage in neonatal rat pups. Human neural stem cell extracellular vesicles improve tissue and functional recovery in the murine thromboembolic stroke model.

Adenosine A2A receptors in bone marrow-derived cells attenuate cognitive impairment in mice after chronic hypoperfusion white matter injury. C-Abl tyrosine kinase mediates neurotoxic prion peptide-induced neuronal apoptosis via regulating mitochondrial homeostasis.

Mol Neurobiol. STI protects neuronal cells from neurotoxic prion protein fragment-induced apoptosis. Extracellular vesicles derived from neural progenitor cells--a preclinical evaluation for stroke treatment in mice.

TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux. J Mol Cell Cardiol. Highly dynamic changes in the activity and regulation of macroautophagy in hearts subjected to increased proteotoxic stress. Front Physiol. Pituitary adenylate cyclase-activating polypeptide attenuates brain edema by protecting blood-brain barrier and glymphatic system after subarachnoid hemorrhage in rats.

CAS Google Scholar. Melatonin alleviates intracerebral hemorrhage-induced secondary brain injury in rats via suppressing apoptosis, inflammation, oxidative stress, DNA damage, and mitochondria injury. The calcineurin-TFEB-p62 pathway mediates the activation of cardiac macroautophagy by proteasomal malfunction.

Circ Res. J Invest Dermatol. Lauric acid alleviates neuroinflammatory responses by activated microglia: involvement of the GPRdependent pathway. Neurochem Res. Polyunsaturated fatty acid receptors, GPR40 and GPR, are expressed in the hypothalamus and control energy homeostasis and inflammation. The histone H3 lysine demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Leonurine suppresses neuroinflammation through promoting oligodendrocyte maturation.

J Cell Mol Med. Toll-like receptor 2 deficiency shifts PrPinduced microglial activation from a neurotoxic to a neuroprotective phenotype. J Mol Neurosci. Available from:. Microglial responses after ischemic stroke and intracerebral hemorrhage. Clin Dev Immunol. Switching of the microglial activation phenotype is a possible treatment for depression disorder. Front Cell Neurosci. Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.

Bliverdin reductase-a improves neurological function in a germinal matrix hemorrhage rat model. PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol. J Diabetes Res. Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury.

Inflammation after intracerebral hemorrhage. Rodent neonatal germinal matrix hemorrhage mimics the human brain injury, neurological consequences, and post-hemorrhagic hydrocephalus. Download references. You can also search for this author in PubMed Google Scholar. JX participated in the research design, experimental performance including animal surgery, Western blotting, and immunohistochemistry, but not the neurobehavioral testing , data analysis, and drafting of the manuscript.

TC provided technical assistance and help with the manuscript preparation. RL discussed the results and edited parts of the manuscript. JF and JHZ participated in the research design and edited the manuscript. HL and JT are the corresponding authors; these authors participated in all aspects of the study, including research design, data analysis, and manuscript preparation. The authors read and approved the final manuscript. Correspondence to Hongwei Lu or Jiping Tang.

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Reprints and Permissions. Xiao, J. J Neuroinflammation 18, Download citation. Received : 08 March Accepted : 01 July Published : 18 July Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative. Skip to main content. Search all BMC articles Search. Download PDF. Abstract Background Germinal matrix hemorrhage GMH is defined by the rupture of immature blood vessels in the germinal matrix, where subsequent hemorrhage enters the subependymal zone and the cerebral lateral ventricles. Methods GMH model was induced in 7-day-old rat pups by an intraparenchymal injection of bacterial collagenase. Results The results demonstrated that GW improved neurological and morphological outcomes after GMH in the short 24 h, 48 h, 72h and long-term days 21— Background Germinal matrix hemorrhage GMH is the most common neurological disorder of preterm infants, which is associated with a high rate of disability and mortality [ 1 ].

Experimental design The current study was performed in four separate experiments. Drug administration Intranasal drug administration Intranasal drug administration was conducted at 1 h, 25 h, and 49 h after GMH induction as described in Zhang et al.

Intracerebroventricular drug administration Intracerebroventricular ICV drug administration was delivered as previously described in Flores et al. Neurological performance Short-term neurobehavioral examination Negative geotaxis and right reflex were performed at 24 h, 48 h, and 72 h post-GMH as previously reported in Feng et al.

Long-term neurobehavioral examination 1. Rotarod test Twenty-eight days post-ictus, rotarod test was conducted to assess the motor impairment as previously described in Keleb et al. Foot fault test Foot fault test was employed to assess changes in locomotor function [ 35 ]. Morris water maze The Morris water maze was used to evaluate spatial learning and memory at days 23—27 after GMH [ 36 ].

Immunofluorescence Immunofluorescence was conducted as previously reported in Pan et al. Western blot Western blot was conducted as previously reported [ 39 , 40 , 41 , 42 , 43 ]. Histological volumetric study At 28 days post-ictus, the rats were euthanized and whole brains were extracted.

Full size image. Conclusions In conclusion, this study is the first to demonstrate that GPR40 agonism via GW ameliorated neurobehavioral impairments by attenuating neuroinflammation and regulating microglia polarization after GMH in neonatal rats. When you buy through our links, we may get a commission.

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